Formulation and Evaluation of Immediate Release Tablet of Telmisartan

ABOUT AUTHOR
Saurabh Kumar*¹, Pravin Gupta¹, Rahul Dev^1
1Sir Madanlal Institute of Pharmacy, Alampur Hauz, Etawah-20600, U.P, India
*E-mail: saurabhkumar8april@gmail.com

Abstract
The main objective of this work is to formulate an immediate release oral solid dosage form of Telmisartan which is considered to be stable, robust quality and pharmaceutically equivalent to that of the reference [marketed] product for the treatment of hypertension and also to develop and evaluate immediate release tablets with different compositions of excipients which will meet the standards to that of the reference product with the subsequent achievement of in vitro correlation with the reference product. The reference product of the Telmisartan is Micardis manufactured by Boehringer Ingelheim, USA. Telmisartan tablets were formulated by using wet granulation method using microcrystalline cellulose as diluent, MCC as binder, crospovidone as disintegrating agent and magnesium stearate as lubricant The prepared tablets were checked for assay as per USP specifications. All the formulations passed the test and the percentage of active ingredient ranges from 96.9 to 96.8%.
Key words: Immediate release tablet, Telmisartan, hypertension.