Formulation and Evaluation of Gastro retentive Floating Tablets of Famotidine

Kotta Kranthi Kumar*, Rahul S. Radke 
Department of Pharmaceutics, S.K.U College of Pharmaceutical sciences, S.K. University, Anantapur
APOTHEKE-2014, 8 Nov 2014, Organized by Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh, India

Abstract
Famotidine, an anti-ulcer drug, suffers from poor bioavailability (50%), as Famotidine is very less soluble in alkaline P^H. Famotidine used in combination with antacids promotes local delivery of these drugs to the receptor of the parietal cell wall. Local delivery also increases bioavailability at the stomach wall receptor site and increases the efficacy of drugs to reduce acid secretion. Thus, the present work is aimed to formulate floating tablets of Famotidine using an effervescent approach for gastro retentive drug delivery system. Floating tablets were prepared using directly compression technique using polymers like HPMC K4M and HPMCK100M for their gel-forming properties. The HPMC alone polymer unable to controlled on release rate it release drug >90% in 4-6 hrs while in combination with Xanthan gum it release >90% in 8 hrs. The results indicate that gas powered gastro retentive floating Tablets of Famotidine containing 40mg HPMCK100M and Xanthan gum provides a better option for controlled release action and improved bioavailability.
Keywords: Famotidine, HPMC K4M, HPMC K100M, Gastric residence time, swelling index.