Formulation and Evaluation of Floating Tablet of Levofloxacin

Sravan Kumar. P *, Sabareesh Reddy. M, Umasankar.K, Alagu Sundaram. M, P. Jaya Chandra Reddy 
Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupathi-517506, Andhra Pradesh, India

Abstract
In the present study, the tablets were prepared by melt granulation method, using the polymer, hydroxy propyl methyl cellulose (HPMC K4M),Carbopol with different amounts and other excipients and sodium bicarbonate and citric acid as gas generating agents. The present study is to develop a floatable drug delivery system of Levofloxacin hemihydrate for sustained drug delivery and gastric retentive property with special stress on optimization of formulations for floating tablets. Thus the study aims to improve the oral bioavailability of the drug and to achieve extended retention in the stomach which may result in prolonged absorption of drug. Tablets were evaluated by different parameters such as weight uniformity, content uniformity, thickness, hardness, IR spectral analysis, in vitro release studies, Buoyancy determination and kinetic analysis of dissolution data, stability studies Levofloxacin floating tablet drug delivery system showed improved in-vitro bioavailability and extended drug release which may favour the reduced dose frequency and patient compliance.
Keywords: Levofloxacin Hemihydrate, Floating tablets, gas generating in vitro release study, Buoyancy determination