Formulation and evaluation of famotidine floating microsphere in cost effective and simple technique

ABOUT AUTHOR
Hase Amit Ramnath*¹, Dr. S.N. Sri Harsha², D. Yashwanth Kumar ³, K.S.S.N. Neelima⁴, B. Poornima Chandran⁵
Department of Pharmacy, NIMS University, Jaipur.
PACIFIC University, Udaipur, Rajasthan.
Krishna Chaitanya Institute of Pharmaceutical Sciences, Madanapalli.
*E-mail: amithase34@gmail.com 

Abstract
The purpose of this research was to prepare a floating drug delivery system of famotidine. The floating microspheres can be prepared for the improvement of absorption and bioavailability of famotidine by retaining the system in the stomach for prolonged period of time. Floating microspheres of Famotidine were prepared using different polymers like ethyl cellulose, hydroxy propyl methyl cellulose, eudragit by emulsion solvent evaporation / emulsion solvent diffusion method. These formulations were subjected to various evaluation parameters in vitro, viz, hardness, friability, uniformity of content, in vitro floating studies, in vitro dissolution studies, all the formulations were good in appearance and showed better physical and mechanical properties. Formulation F4 containing Poly ethylene oxide and famotidine in the ratio of 1:2 and also the Formulation F10 containing Eudragit & Famotidine in the ration of 1:2 was found to be the best formulation in terms of drug release and was subjected for IR and stability studies. The results indicated that the significant effect was observed of increased polymer concentration, on said parameters in each case. The results indicated that the significant effect was observed of increased polymer concentration, on said parameters in each case. 
Key words: Famotidine, Eudragit, floating microspheres Poly ethylene oxide, In vitro dissolution studies, IR spectroscopy.