Formulation and Evaluation of Compressed Coated Tablets of Mosapride Citrate for Colonic Delivery

Yeswanth Reddy Musukula*
Department of Pharmaceutics, Synapse Life Sciences, Nakkalagutta, Hanamkonda, Warangal, Telangana, India

A B S T R A C T
The objective of the present research study is to develop compression coated tablets of Mosapride citrate with a view of minimizing the drug release in the physiological envinorment of stomach and small intestine and to ensure maximum drug release in the physiological envinorment of colon by employing Guar gum as a compression coat over the Mosapride citrate core tablets. The standard graph of Mosapride citrate was constructed in 0.1N Hcl and 7.2 pH phosphate buffer. FTIR spectra revealed that there was no interaction between the drug and the excipients. The study indicated that the prepared formulations were good as the physicochemical parameters were found to be within the pharmacopoeial limits. In vitro drug release studies were conducted for 2hrs in 0.1N Hcl and in 7.2 pH phosphate buffer up to 24hrs.All the formulations remained intact for 24hr. As the concentration of polymer is increased the release rate of drug was decreased. All the formulations followed Zero order kinetics, showed good correlation in Higuchi Kinetics clearly indicating that the drug release mechanism was predominantly Diffusion controlled. When the data was fitted to Korsmeyer’s- Peppas equation the slope values suggested that the release of Mosapride citrate from all the formulations followed Non Fickian diffusion. From the study we found that the tablets compression coated with Guar Gum would be potential as a formulation in delivering the drug to the colon as well as for the effective and safe therapy of inflammatory bowel disease (IBD).
Keywords: Mosapride citrate (MSP), inflammatory bowel disease (IBD), Guar gum, Compression coated.