Formulation and Characterization of Amiodarone Liquisolid Compacts

T. Pragna*, M. Nirosha, S. Sai Vikas, D Tharun, K. Pavan Kumar
Department of Pharmaceutics, JNTUA-Oil Technological & Pharmaceutical Research Institute, Ananthapuramu, A.P, India.

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Slow dissolution rate of poorly water soluble drugs faces major challenge in the drug development and delivery processes. Liquisolid compact technology is the most latest and novel approach for overcoming the trouble of inadequate solubility of the poorly soluble drugs. Amiodarone having poor solubility in water and used for the treatment of both supraventricular and ventricular arrhythmias. The main aim of the present study was to improve absorption efficiency and dissolution behavior of Amiodarone through Liquisolid technique. The main components of liquicompact system includes PEG 400 as solvent, Avicel PH 102 as carrier, Aerosil 200 as coating material and Cross Carmellose Sodium as disintegrant. Liquisolid compact tablets were prepared and evaluated for their tabletting properties which were found to be within the acceptable range. The prepared tablets showed good wettability, rapid disintegration and acceptable dissolution rate when compared to the marketed product. FT-IR studies revealed the there was no interaction between drug and excipients. All the formulations exhibited higher drug release when compared to marketed tablets. Hence liquisolid technique will be an easy and promising approach for enhancing the solubility and dissolution of poorly soluble drugs.
Keywords: Amiodarone, PEG 400, Avicel PH 102, Aerosil 200, Cross Carmellose Sodium, Liquisolid compact technology.