Formulation and Characterisation of Pulsatile Drug Delivery System of Bisoprolol Fumarate Prepared by Press Coated Method

Nagamani*, J. Sreedevi, Y. Ankama Chowdary
NRI College of Pharmacy, Krishna District, Andhra Pradesh, India

A B S T R A C T
Pulsatile dosage form taken at bed time with a programmed start of drug release in the early morning hours, can prevent a sharp increase in the incidence of heart attacks during the early morning hours. In the present study, an attempt was made to design and characterize pulsatile drug delivery system in order to release the drug after 7-8hr in the intestine, and intentionally delaying the drug absorption from therapeutic point of view in the treatment of heart attacks, where peak symptoms are observed in the early morning. Thus this study attempts to design and evaluate a chronomodulated drug delivery system of  Bisoprolol Fumarate selectively blocks catecholamine stimulation of β1-adrenergic receptors in the heart and vascular smooth muscle. Eight formulations (F1–F8) of core tablets were prepared by direct compression technique and evaluated for various physico chemical parameters. In vitro drug release study of  Bisoprolol Fumarate core tablets revealed F6 as best formulation and press coated and enteric coated using different polymers like Ethyl cellulose and Eudragit L100 (C1 – C5) to find out the changes in the release rate of the Bisoprolol Fumarate  from enteric coated tablets. This enteric coat has enabled us to achieve definite non release lag phase for 8 hours.
Keywords: Bisoprolol Fumarate, Pulsatile drug delivery, Ethyl cellulose, Eudragit L100.