Fabrication and evaluation of Lornoxicam matrix tablets with natural gums

Sreelekha M¹*, Hindustan Abdul Ahad¹, Faheem B¹, Ramesh Dhani^2
1PG Department of pharmaceutics, Balaji College of pharmacy, Ananthapuramu, Andhra Pradesh, India
²Dept. of Pharmaceutical Chemistry, Ratnam Institute of Pharmacy, SPSR Nellore, Andhra Pradesh, India-524346
APOTHEKE-2014, 8 Nov 2014, Organized by Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh, India

Abstract
The aim of the proposed work is to study the effect of natural gums like Xanthan gum, Acacia nilotica and Buteamonosperma on drug release. The present plan of work includes the preparation of matrix tablets by using three different natural gums with four varying concentrations and its comparison with marketed tablets. Lornoxicam was took as a model drug in the present study. The formulated tablets were tested for mechanical properties, friability, swelling behaviour, in vitro drug release pattern and the dissolution data was treated with mathematical modelling and the optimized formulation drug release was compared with marketed sample was tested for accelerated stability studies. The formulated tablets were found to have good mechanical properties, good swelling properties. The in vitro dissolution data was perfectly fitting to zero order release. The stability studies revealed that the tablets retain their characteristics even after stressed storage conditions. From this study it was concluded that the dried Xanthan gum, Acacia nilotica and Buteamonospermagums can be used as a matrix forming material for making sustained release matrix tablets
Keywords: Xanthan gum, Acacia nilotica and Buteamonosperma