Evaluation of Anti Ulcer Effect of Polyalthia Longifolia Leaves in Albino Rats

Bhupalam Pradeep kumar, Y Padmanabha Reddy, N Devanna, K Somasekhar Reddy, A Sudheer
Raghavendra Institute of Pharmaceutical Education and Research, Anantapuramu-515721.

A B S T R A C T
The anti-ulcer activity of Polyalthia longifolia has been carried out in albino rats. Antiulcer activity of ethanolic extract of leaves was studied in rats, in which gastric ulcers were induced by oral administration of indomethacin (20 mg/kg). The extract was administered in the dose of 100 mg and 200 mg/kg to the test group of animals for three consecutive days. The rats were subjected for ulcer index and gastric acid evaluation. The reduction of ulcer index as well as gastric acid output in extract treated animals was found to be statistically significant with respect to control animals. The extract exhibited ulcer protection activity in dose dependant manner. (878/ac/05/CPCSEA/004/2011)._.
Keywords: Polyalthia longifolia, anti-ulcer, indomethacin induced ulcer, ulcer index.