Discerning Sarcosine Biosensor in the Presence of Elevated Concentrations of Ascorbic Acid and Uric Acid

S. Brillians Revin*
Assistant Professor, Department of Chemistry (MSc., Ph.D, Post-doctoral Research Scientist-South Korea, 2012-2014), Francis Xavier Engineering College, Scad Group of Institutions,Tirunelveli, India.

A B S T R A C T
The electrochemical response of Sarcosine (Sar) in the presence of elevated concentrations of Ascorbic acid (AA) and Uric acid (UA) is reported by differential pulse voltammetry (DPV) using an electro-polymerized film of 3-amino-5-mercapto-1,2,4-triazole on glassy carbon (p-AMTa) electrode for the first time. Bare glassy carbon (GC) electrode fails to show voltammetric signal for Sar. However, p-AMTa electrode shows a clear voltammetric signal for Sar at 0.96 V. Further, p-AMTa electrode separates the voltammetric signals of AA, UA and Sar in a mixture with the potential differences of 200 mV for AA-UA and 680 mV for UA-Sar. The selective determination of Sar even in the presence of 40-fold high concentrations of AA and UA was successfully demonstrated in this work.
Keywords: Polymer; Sarcosine; Biosensor; Ascorbic acid; Uric acid