Design and In-Vitro Characterization of Repaglinide Tablets for Controlled Release Drug Delivery System

B. Kalyani¹, Gampa Vijaya Kumar*², P. Sridhar³, K. Someshwar^4
1CVM College of Pharmacy, Keesara, Karimnagar, Telangana, India
²Professor & Principal, CVM College of Pharmacy, Karimnagar, Telangana, India
³Assistant professor, CVM College of Pharmacy, Karimnagar, Telangana, India
⁴Managers, Formulation R&D, KP Labs (A Division of KDPL), Kothapet, Hyderabad, Telangana, India

A B S T R A C T
Oral drug delivery is the most preferred and convenient option as the oral route provides maximum active surface area among all drug delivery system for administration of various drugs. The attractiveness of these dosage forms is due to awareness to toxicity and ineffectiveness of drugs when administered by oral conventional method in the form of tablets & capsules. The aim of the present study was to develop and controlled release formulation of Repaglinide to maintain constant therapeutic levels of the drug for over 12 hrs. Various grades of HPMC were employed as polymers. Repaglinide dose was fixed as 2 mg. Total weight of the tablet was considered as 75 mg.  Polymers were used in the concentration of 12 and 16 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F11) showed better and desired drug release pattern i.e., 97.82 % in 12 hours. It followed zero order release kinetics mechanism.
Keywords: Repaglinide, different grades of HPMC polymers, Controlled Release tablets