Design and Evaluation of Sustained release matrix tablets for Tramadol Hydrochloride (TH) Melt granulation technique

B. Ranganayakulu*, V.Krishnaveni¹, Dr. S. Mohammed Yusuf^2
*,2 Associate Professor,  Srinivasa institute of Pharmaceutical Sciences, Proddatur, A.P., India.
¹Srinivasa institute of Pharmaceutical Sciences, Proddatur, A.P. India.

A B S T R A C T
The objective of the present investigation was to design and evaluate sustained release matrix tablets for Tramadol Hydrochloride (TH) with Compritol 888 ATO and Precirol ATO 05 by melt granulation technique. Sustained drug delivery system to achieve prolonged therapeutic effect by continuous release of drug for extended period of time after single dose administration.  TH is a centrally acting synthetic opioid analgesic. Twelve formulations of sustained release matrix tablets were prepared using polymer such as Compritol 888 ATO or Precirol ATO 05. The evaluation results revealed that all formulations comply with the specification of official pharmacopoeias and/or standard reference with respect to general appearance, content uniformity, hardness, friability and buoyancy.  Out of all the formulations, MG8( TH:Compritol888ATO:PrecirolATO5,1:2:1) showed maximum retardation of  drug release which may be  attributed to high lipophilicity, high melting point(65°Cto77°C)of Compritol888ATO. Matrix tablets of TH prepared by melt granulation technique shows retardation of drug release more effectively than tablet prepared by direct compression of physical mixture.
Keywords: Tramadol Hydrochloride (TH), Sustained release, Compritol 888 ATO, Precirol ATO 05, Melt granulation technique, Formulation