Design and Evaluation of Fast Dissolving Tablets of Fexofenadine by Using Novel Super Disintegrants

B. Venkateswara Reddy*, G. Srikanth, K. Navaneetha
Department of Industrial Pharmacy, St.Paul’s College of Pharmacy, Hayathnagar, Hyderabad, R.R.Dist-501510, India

A B S T R A C T
The purpose of this research was to formulate tasteless complexes of Fexofenadine Hydrochloride with Amberlite IRP-64 and to formulate tasteless complex into Orally-Disintegrant tablets (ODT) for the treatment of allergic rhinitis & chronic idiopathic urticaria. Tasteless Drug resin complexes (DRC) were prepared using combination of Amberlite IRP-64 & drug in different ratio (1:1, 1:2 & 1:3) and evaluated for different factor affecting Drug-Resin Complexation, Complexation time, stirring time, soaking time, temperature, and effect of pH on Fexofenadine Hydrochloride loading on Amberlite IRP-64.The values of precompression parameters evaluated, were within prescribed limits and indicated good free flowing properties. The tablets were evaluated for post-compression parameters such as weight variation, hardness, and friability, wetting time, content uniformity, disintegration time and dissolution. The study conclusively demonstrated significant taste masking of API and rapidly dispersible and dissolution. Maximum loading was obtained at drug–resin ratio 1:1, pH 6-7, temperature 60 ºC, soaking time 60 min and stirring time 5-6 hr. Formulation F-9 containing Amberlite IRP-64 & CSS show optimum result among all formulation. Formulations F-9 was found to be palatable with in vitro disintegration time of 30s, dissolution studies showed complete release of F-9 within 30 min.
Keywords: Fexofenadine Hydrochloride, Fast-Disintegrating tablets (FDT), Amberlite IRP-64, In-vitro drug release