Design and Evaluation of Effect of Disintegration Agents in Ciprofloxacin Hydrochloride

Pudi Venkata Prasad*¹, Kavitha G², Adapa Sivarami Reddy^3
1Nimra College of Pharmacy, 4-90 Nimra Nagar, Ibrahimpatnam, Vijayawada, A.P, India-521456
²Department of Pharmaceutics, Seshachala College of Pharmacy, Puttur, Chittoor, A.P, India-517 583
³Vignan Pharma​cy College, Vadlamudi post, Chebrolu Mandal, Guntur, A.P, India-522213

A B S T R A C T
Drug release from a solid dosage form can be enhanced by addition of suitable disintegrants. In more recent years, increasing attention has been paid to formulating fast dissolving and/or disintegrating tablets that are swallowed, but also orally disintegrating tablets that are intended to dissolve and/or disintegrate rapidly in the mouth. Superdisintegrants are generally used at a low level in the solid dosage form, typically 1-10 % by weight relative to the total weight of the dosage unit. Examples of super disintegrants are croscarmellose sodium, crospovidone, sodium starch glycolate that represent example of cross-linked cellulose, cross-linked polymer and a cross-linked starch respectively. The stronger the binder, the more effective must be the disintegrating agents in order for the tablet to release its medication. Ciprofloxacin hydrochloride, a synthetic fluoroquinolone, it is a bactericidal agent having a mode of action was achieved through inhibition of DNA gyrase, is an essential component of the bacterial DNA replication system. Pre-compressional characteristic of Ciprofloxacin HCl Tablets Using FA as disintegrants for various batches like FA, FB, FC, FD, FE, includes the formulation FA 1 to FA 3 having the angle of repose value 26.56 to 29.47, Bulk Density values 0.3832 to 0.3850, The Tap density values 0.4466 to 0.4566, Compressibility Index values 14.0999 to 15.1992, Hausner ratio values contain 1.1641 to 1.1792.  The FB batches disintegrants FB 1 to FB 3 having the angle of repose value 28.19 to 29.31, Bulk Density values 0.3421 to 0.3575, The Tap density values 0.3981 to 0.4041, Compressibility Index values 6.5789 to 15.3427, Hausner ratio values contain 1.0704 to 1.1812.  The disintegration and dissolution profile and also perform stability studies for various disintegrants.
Keywords: Disintegration Agents, Ciprofloxacin Hydrochloride, Disintegration, Dissolution, Stability studies.