Cascade Synthesis and Biological Activities of Schiff Base

P. Venkateswara Rao, A.V.G.S. Prasad*¹, P.S.S. Prasad*^2
1Department of Chemistry, Nizam College (Autonomous), Hyderabad, Telangana, India.
²Drug Control Administration, Hyderabad, Telangana, India.

A B S T R A C T
In the present study an intermolecular reductive Schiff base formation from nitroarene and benzaldehyde to yield diarylimine is carried out in the presence of iron powder and ammonium chloride. New Schiff base ligand synthesized from 4 nitro toluene with 2-hydroxy-3-methoxy benzaldehyde. The ligand and metal complexes have been screened for their microbiological activity. The experimental results suggest that Schiff base and metal complex ligands are more potent in anti-bacterial activities.
Keywords: Tandem reaction, intermolecular reduction, metal complexes, green chemistry biological properties.