Antiulcer Activity of Symphytum Officinale Linn Root on Wistar Albino Rats

Pradeep Kumar Choda¹, Namani Srilatha¹, Vijaya Kuchana¹, D. Yashwanth Kumar², ¹D.S.S.N. Neelima
¹Department of Pharmacology, Teegala Krishna Reddy College of Pharmacy, Hyderabad, Telangana, India
²Scientific and Applied Research Center, Hyderabad, Telangana, India

A B S T R A C T
The effect of Methanolic root extract of Symphytum officinale Linn was investigated in rats to evaluate the anti-ulcer activity by using Aspirin plus pyloric ligation model on experimentally induced gastric ulcer. The parameters taken to assess anti-ulcer activity were volume of gastric secretion, PH, free acidity, total acidity and ulcer index. The results indicate that the methanolic extract significantly (P< 0.001) decreases the volume of gastric acid secretion, PH, free acidity, total acidity and ulcer index with respect to control.
Keywords: Symphytum officinale Linn, Anti-ulcer, Anti-secretory