Anticonvulsant Activity of Various Synthetic Compounds on Experimental Animals

Mani Mala Velayutham*¹, Cholaraja Kamatchi², Jeyaraman Amutha Iswarya Devi³
Department of Pharmaceutical Chemistry, Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil-626126, Srivilliputtur (via) Tamil Nadu, India

A B S T R A C T
Anti-convulsion drugs are intended for the treatment of convulsive disorders in living system. Convulsions may arise due to many reasons most of the animal techniques used for evaluating anti – epileptic drugs. 7-phenylcarbamoylheptanoic acid, 7- (4–Methyl – 2-oxo–2H–chromen–6–ylcarbamoyl)– heptonic acid, 4-[(pyridine-3-ylmethoxy carbonyl amino)-methyl]-benzoic acid, 4-(Benzyloxycarbonylamino-methyl)-benzoic acid were synthesized from laboratory. In this experiment, the entire synthesized drugs (CMP I–CMP IV) exhibited anticonvulsant activity. The test is started 30 min after i.p. injection. Male Swiss albino mice are stimulated through pinna electrodes the resultant seizure in normal mice shows a tonic phase of limb flexion around 2 seconds, followed by full tonic extension phase around 10 -13 seconds and a few clonic jerks there after the number of post – tonic as physical death are noted.
Keywords: Anti convulsant activity, CMP I-CMP IV, MES, Seizures.