Anti diarrheal activity of ethsnolic extract of the Memcyclon Edule leaves in castor oil induced diarrhea model in mice

U. Venkatesh1*, Sri Rama Radha1, P. Suresh1, G. Sravan Reddy2
1St John’s College of Pharmacy, Yemmiganur, Kurnool, Andhra Pradesh
2Hi-Q Herbals, Kothapet, Hyderabad, Telangana

A B S T R A C T
Diarrhoeal disease is often a leading source of mortality and morbidity, especially among   children in developing countries causing a major healthcare problem. As per suggestion of WHO, treatment of diarrhoea with traditional medicine is the main focus of our present studies. The present study is designed to evaluate the anti-diarrhoeal activity of crude methanol extract of Memecylon edule. Crude methanol extracts are obtained by in vacue methods and its fractionating is done by Kupchan partitioning method. The anti-diarrhoeal activity is screened by castor oil-induced diarrhoea, castor oil-induced enteropooling and gastrointestinal motility test. Alcoholic extract of the leaves of  Memecylon  edule was reduced castor oil-induced diarrhea  significantly (P<0.05) and showed the dose dependent inhibition of diarrheal defaecation of  22.41% to 56.89 % respectively  at the dose of 200mg/kg  and 400mg/kg body weight compared to control. It is concluded that, leaves of Memecylon edule contains bioactive natural substances with anti-diarrhoeal properties. These attributes may give a justification for your use of Memecylon edule in diarrhoea management by traditional healers.
Keywords: Memecylon edule, Castor oil, Loperamide, Anti-diarrhoreal activity