Anti-diabetic activity of ethanolic extract of Psychotria octosulcata in streptozotocin and high fat diet induced diabetes in male wister rats.

K. Naveen*, P. Naresh Babu
Department of Pharmacology, Ratnam Institute of Pharmacy, Pidathapolur, SPSR Nellore, Andhra Pradesh, India

A B S T R A C T
Antidiabetic activity of psychotria octosulcata Linn. whole plant ethanolic extract-Shade dried and coarsely powdered plant (1 kg) was extracted successively with soxhlation method. The ethanolic extract of different doses of 200 and 400 mg/kg b. w and Pioglitazone (2 mg/kg), were evaluated for Antidiabetic activity using Strptozotocine (50mg/kg) induced Diabetic in rats. The biochemical parameters assessed were cholesterol, triglycerides, low density lipoproteins (LDL), and serum biomarkers of liver and kidney like SGOT, SGPT, Total proteine and serum creatinine. Test drug also shown significantly reduced glucose levels in diabetic rats. The extracts also showed reduction in the feed and water consumption of diabetic rats when compared with the diabetic control. The histopathological results of treated groups showed the regenerative/protective effect on β-cells of pancreas in diabetic rats. The current study revealed the antidiabetic potential of Artemisia amygdalina being effective in hyperglycemia and that it can effectively protect against other metabolic aberrations caused by diabetes in rats, which seems to validate its therapeutic traditional use.
Keywords: Antidiabetic activity, Psychotria octosulcata, Pioglitazone, Streptozotocine