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Poonam Lodhi*1, Neeraj Tandan2, Neera Singh1, Monu Kumar2 and Divayansh Kumar3
1Environmental Endocrinology and Biomedical Research Unit, Department of Zoology, Meerut College, Meerut-250003, India.
2Scientific and Applied Research Center, Meerut, U.P., 250001, India.
3D.A.V. (P.G.) College, Bulandshahr, U.P., 203001, India.
Abstract
The present study was aimed to investigate the ability of some natural antioxidants present in CSE on haematological profile of male albino rats against ethanol toxicity. The rats were divided into 4 groups. Group 1 fed on a standard diet (controls), group 2 received a dose of 0.25ml/100g body weight (ethanol treated), group 3 and group 4 treated with ethanol and CSE (5mg/kg bw and 10mg/kg bw) for 15 days. The ethanol administration significantly (P<0.05) decreased the levels of red blood cell count (RBCs count) counts, haemoglobin percentage (Hb%), packed cell volume (PCV%), total leucocyte count (TLC) and differential leucocyte count (DLC count) comparing with the control group of rats. However, the oral feeding of CSE to rats after 30 minutes of ethanol ingestion caused significant (P<0.001) improvement in the levels of above parameters. Ethanol metabolism led to the formation of acetaldehyde, a highly cytotoxic compound responsible for the oxidation of proteins, erythrocyte abnormalities and hemolysis. It causes an oxidative stress resulting from increased free radical production and decreased antioxidant defence. The data of this study suggested that, CSE has the ability of natural antioxidants to prevent the changes in the above blood profile against the ethanol toxicity by enhancing the levels of total antioxidant status.
Keywords: Ethanol, Camellia sinensis extract (CSE), RBCs, Hb%, PCV, TLC
