Aceclofenac Sodium Nanoemulsion: an Approach to Improve Anti-Inflammatory Therapy

S. Lakshmana Prabu*, S.P. Sharavanan, A. Shanmugarathinam, K. Elaiyaraja 
Department of Pharm Tech., BIT Campus, Anna University, Tiruchirappalli–620 024.
NCADDD, 25 July 2014, Organized by Department of Pharmaceutical Technology, Anna University, BIT Campus, Tiruchirappalli–620024, Tamil Nadu, India

Abstract
Nowadays drugs with low aqueous solubility and high permeability are present in high proportion. Poorly water-soluble compounds are frequently dropped in early stages in drug discovery process. Poorly-water soluble compounds are difficult to develop into drug products by using conventional formulation techniques. Nanotechnology is seen as a promising approach for the enhancement of drug solubility. In this study, we present an approach of nanosizing a drug/polymeric complex to increase both solubility and dissolution rate of poorly-water soluble drug aceclofenac, which is widely used as anti-inflammatory drug. Nanoemulsions were prepared by solvent evaporation technique with the aim to improve anti-inflammatory therapy. The prepared formulation was evaluated for drug excipients compatibility study, polydispersity index, particle size analysis, surface morphology, zeta potential, drug release features and stability. These study results indicate the suitability of formulation procedure for preparation of nanosized poorly-water soluble drug formulation with significantly improved in vitro dissolution rate and fast onset of therapeutic drug effect.
Keywords: Aceclofenac, Nanoemulsion, Span 80, Tween 80, Dissolution Anti-inflammatory.