Acacia cumanensis plant gum as release retardant in matrix tablet formulation taking Aceclofenac as model drug

About author
*Hindustan Abdul Ahad², Anuradha CM¹*, Abhilash A², Prabhuraj KJ², Swapna K^2
1Department of Biotechnology, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India
²Department of Pharmaceutics, Balaji College of Pharmacy, Anantapur, Andhra Pradesh, India
* e-mail : abdulhindustan@rediffmail.com

ABSTRACT
The present work was aimed to explore the release retarding properties of Acacia cumanensis plant gum in matrix tablets using Aceclofenac as model drug. Physicochemical properties of dried powdered Acacia cumanensis plant gum were studied. Various formulations of Aceclofenac Acacia cumanensis gum were prepared. The prepared tablets were evaluated for physicochemical properties, swelling index, drug release. The prepared tablets were found to have better uniformity of weight, swelling behavior, drug content and release characteristics. The study concluded that Acacia cumanensis plant gum can be used as a matrix forming release retardant in once daily sustained release matrix tablets.
Key words: Aceclofenac, Acacia cumanensis, matrix tablets, release retardant.