A Review on Flash Chromatography

Dandu Girija^1*, Akkimi Padma², Basu Venkateswara Reddy^3
1,2Assistant Professor, Department of pharmaceutical Analysis, Sankar Reddy Institute of Pharmaceutical Sciences, Bestavaripeta, Prakasam, A.P-523370.
³Professor, Department of Pharmaceutics, Sankar Reddy Institute of Pharmaceutical Sciences, Bestavaripeta, Prakasam, A.P-523370.

A B S T R A C T
Chromatography was most widely used analytical technique of the separation of mixture of the components with the help of stationary phase and mobile phase. Flash chromatography was one of the advance techniques of normal phase chromatography. In this technique separation of mixture of the components from few milligrams to up to industrial kg scale. Flash chromatography was parallel to the HPLC. Stationary phase purpose glass columns are used and packed with silicagel. The present review explains the various components in flash chromatography and applications. Flash Chromatography is a simple, fast, cost effective Preparative Liquid Chromatography approach. Separations are based upon traditionally obtained TLC results which are simply extrapolated to preparative scale.
Keywords: Flash chromatography, Sillica gel, glass column, Normal phase