A Novel Pharmaceutical Microscopic Vesicle: Liposome

Patel Chirag J*1, Satyanand Tyagi2, Patel Kanu J3, Patel Tushar4, Patel Harnish K5, Patel Priyanka H6
1Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
2Founder, President & CEO, Tyagi Pharmacy Association, Chattarpur, New Delhi, India-110074.
3Sharda School of Pharmacy, Pethapur, Gandhinagar, Gujarat, India.
4Aditya Bangalore Institute for Pharmacy Education & Research, Bangalore, Karnataka, India.
5Editor-In-Chief, IJPRBS Journal, Gujarat, India.
6Director, Research Scholar Hub, Gujarat, India.

Abstract
Liposomes are simple microscopic vesicles in which an aqueous volume is entirely enclosed by a membrane composed of lipid bilayers. Liposomes are defined as structure consisting of one or more concentric spheres of lipid bilayers separated by water or aqueous buffer compartments. The liposomes have emerged as most practically useful carriers for in-vivo drug delivery as majority of reports has concentrated on the use of phospholipid vesicles or liposomes as potential drug carrier systems. The water soluble compounds/drugs are present in aqueous compartments while lipid soluble compounds/drugs and amphiphilic compounds/drugs insert themselves in phospholipid bilayers. The present review focuses upon the advantages, disadvantages, mechanism, classification, method of preparation, characterization and application of liposomes.
Key words: Liposomes, Phospholipid, Stability, Lipid bilayers